Decision support system to evaluate VENTilation in ARDS
The purpose of this study is to compare mechanical ventilation in ARDS patients following advice from the Beacon Caresystem to that of standard care. The protocol has been amended to include COVID-19 patients.
Status: Open and recruiting at RBHT
Type: Interventional
Funder: not available
Sponsor: Imperial College of Science, Technology and Medicine
CI: Dr Brijesh Patel
IRAS-Number: 266521
CPMS-ID: 43529
Approval Date: 13 April 2020
Description:
To study a novel intervention (device) or randomised clinical trial to compare interventions in clinical practice (managemeet of care & active monitoring)
Inclusion:
- Invasive mechanical ventilation.
- Within 1 week of a known clinical insult or new or worsening respiratory symptoms
- Within 7 days of an acute and potentially reversible episode of acute respiratory failure (as determined by the treating physician).
- Chest radiograph with bilateral infiltrates consistent with evidence of pulmonary oedema but not fully explained by cardiac failure.
- Hypoxaemia as defined by PaO2/FiO2 of < = 300mmHg (or < = 40kPa) (pre-ECMO PaO2/FiO2 will be used should patient be placed on extracorporeal support).
For Healthy Volunteers criteria:
- 18 years or older
- Able to consent
- Have mental capacity
Exclusion:
- Age < 18 years old.
- The absence of an arterial catheter for blood sampling at study start.
- Consent declined.
- Over 7 days of mechanical ventilation.
- Treatment withdrawal imminent within 24 hours.
- DNAR (Do Not Attempt Resuscitation) order in place
- Severe chronic respiratory disease requiring domiciliary ventilation (except for sleep disordered breathing)
- Veno-ArterialVA ECMO ECMO
For Healthy Volunteers criteria:
- Blood borne viruses: HIV, Hep B, Hep C
- Blood taken in the last 7 days
- Under doctor for investigation
- Haematological disease
- Currently suffers from infection
- Needle phobia
- Problems with veins / vessels
- Refusal